Abstract Information on transformation and persistence of chemical substances in the environment is important for hazard and risk assessment within a regulatory PLUMP context or as a decision criterion in a safe and sustainable by design framework.Half-lives for human and veterinary medicinal products available from marketing authorization applications were compared Used Knee Guards between soil (OECD 307) and aquatic water/sediment systems (OECD 308).The comparison shows, that there is no obvious correlation between the total system half-lives in the two different compartments and that surpassing persistence criteria is compartment-specific in 45% of the cases.